Along with the Nittany Lions falling 20-13, No. 8 Clemson fell to Louisville, No. 10 Iowa State fell to Texas Tech and No. 11 Texas A&M fell to South Carolina on the road. Each team still has a chance at the CFP, with Penn State likeliest to reach the 12-team field, however, the loss makes things trickier for the Tigers, Cyclones and Aggies.
The Buckeyes jumped to the best odds to win the national championship after their win over Penn State via BetMGM, with Georgia, Oregon, Texas and Miami following shortly behind.
Here are the updated College Football Playoff odds after Week 10 of the regular season:
College Football Playoff odds
Odds courtesy of BetMGM as of Sunday, Nov. 3
1. Ohio State +350
2. Georgia +400
3. Oregon +450
4. Texas +550
5. Miami +1100
T-6. Alabama +1800
T-6. Tennessee +1800
8. Penn State +2200
9. Notre Dame +3000
10. Ole Miss +3500